Many of us have encountered a version of what Zachary Horton calls the "cosmic zoom"--a visual journey through the many scales of the universe, from the microscopic to the cosmic. Most of our daily perception operates at a level of scale somewhere between that of quarks and galaxies, and it is this comfort with the immediately visible everyday world that the cosmic zoom unsettles. In Mediating Scale, Horton uses the history of the cosmic zoom to explore how (...) that scale itself has been constructed over the past seventy years. How has cosmic zoom media influenced scientific and popular understanding of the unseen world and how it may be known, accessed, and exploited? Horton insists that scale is the key to understanding and addressing major contemporary issues including climate change and big data, but people working on issues of scale in various disciplines often talk past each other. Horton starts by sketching four common ways of thinking about scale derived from cartography, physics, engineering/biology, and mathematics. He then shows how these concepts operate in various disciplines, explains why they don't fit together, and puts forth a new, transdisciplinary theory and vocabulary of scale, one that links the natural sciences, humanities, and social sciences. In this ambitious work, scale becomes a foundation for rethinking the relationships between knowledge, mediation, and environment. (shrink)

Trump’s election renewed discussion about the Electoral College, mostly centered on its disparity with the popular vote. Yet much commentary about the Electoral College neglects its original purpose grounded in the Founders’ concern to provide for indirect election to many important offices. The Founders’ project entailed determining the people’s aptitude to elect the types of individuals desirable for high office, in an attempt to harmonize their dual commitments to political right and political legitimacy. The Electoral College’s function was soon frustrated (...) by the rise of political parties, yet parties came to serve at least part of that function, with party leaders standing as a moderating force between the people and the presidency. However, the 2016 elections suggest that parties no longer play this intermediary role effectively. Examining the steps that led to this result, we seek to provide a reminder of the enduring thesis that the dangers inherent in republicanism require creative republican remedies. (shrink)

ABSTRACTWe investigated the impact of emotions on learning vocabulary in an unfamiliar language to better understand affective influences in foreign language acquisition. Seventy native English speakers learned new vocabulary in either a negative or a neutral emotional state. Participants also completed two sets of working memory tasks to examine the potential mediating role of working memory. Results revealed that participants exposed to negative stimuli exhibited difficulty in retrieving and correctly pairing English words with Indonesian words, as reflected in a lower (...) performance on the prompted recall tests and the free recall measure. Emotional induction did not change working memory scores from pre to post manipulation. This suggests working memory could not explain the reduced vocabulary learning in the negative group. We argue that negative mood can adversely affect language learning by suppressing aspects of native-language processing and impeding form-meaning mapping with second language words. (shrink)

Background: Freezing of gait is a common symptom in Parkinson’s disease and can be difficult to treat with dopaminergic medications or with deep brain stimulation. Novel stimulation paradigms have been proposed to address suboptimal responses to conventional DBS programming methods. Burst-cycling deep brain stimulation delivers current in various frequencies of bursts, while maintaining an intra-burst frequency identical to conventional DBS.Objective: To evaluate the safety and tolerability of BCDBS in PD patients with FOG.Methods: Ten PD subjects with STN or GPi DBS (...) and complaints of FOG were recruited for this single center, single blinded within-subject crossover study. For each subject, we compared 4, 10, and 15 Hz BCDBS to conventional DBS during the PD medication-OFF state.Results: There were no serious adverse events with BCDBS. It was feasible and straightforward to program BCDBS in the clinic setting. The benefit was comparable to conventional DBS in measures of FOG, functional mobility and in PD motor symptoms. BCDBS had lower battery consumption when compared to conventional DBS.Conclusions: BCDBS was feasible, safe and well tolerated and it has potential to be a viable future DBS programming strategy. (shrink)

Theory‐of‐mind (ToM) is an integral part of social cognition, but how it develops remains a critical question. There is evidence that children can gain insight into ToM through experience, including language training and explanatory interactions. But this still leaves open the question of how children gain these insights—what processes drive this learning? We propose that analogical comparison is a key mechanism in the development of ToM. In Experiment 1, children were shown true‐ and false‐belief scenarios and prompted to engage in (...) multiple comparisons (e.g., belief vs. world). In Experiments 2a, 2b, and 3, children saw a series of true‐ and false‐belief events, varying in order and in their alignability. Across these experiments, we found that providing support for comparing true‐ and false‐belief scenarios led to increased performance on false‐belief tests. These findings show that analogical comparison can support ToM learning. (shrink)

Medical assistance in dying was legalized in Canada in 2016. As of July 2017, approximately 2149 patients have accessed MAID. There remains no national-level data on the perspectives of future physicians about MAID or its changing legal status. We provide evidence from a national survey of Canadian medical students about their opinions, intentions, and concerns about MAID. From October 2016 to July 2017, we distributed an anonymous online survey to all students at 15 of Canada’s 17 medical schools. The survey (...) collected data on respondent socio-demographic characteristics, features of their medical education, intentions for medical practice, and perspectives on MAID. We analyzed responses using univariate descriptive and stepwise multivariate logistic regression. In 1210 completed surveys, 71% of respondents reported being willing to provide MAID under a legal framework that permits it. Non-religious respondents reported greater willingness to participate in MAID than respondents of any religious affiliation. Frequency of religious attendance was inversely associated with willingness to provide MAID. Medical students born in Québec were more willing to provide MAID than respondents from other provinces. Age, sex, socioeconomic status, year of medical study, previous academic major, and rural/urban city of birth were not associated with willingness to provide MAID. As the current class of medical students becomes the first cohort of new physicians to enter Canada’s changing medical and legal landscape around MAID, our findings inform the public debate by examining attributes associated with support or opposition to the practice. (shrink)

While outcomes for children with T-cell acute lymphoblastic leukemia have improved dramatically, survival rates for patients with relapsed/refractory disease remain dismal. Prior studies indicate that glucocorticoid resistance is more common than resistance to other chemotherapies at relapse. In addition, failure to clear peripheral blasts during a prednisone prophase correlates with an elevated risk of relapse in newly diagnosed patients. Here we show that intrinsic GC resistance is present at diagnosis in early thymic precursor T-ALLs as well as in a subset (...) of non-ETP T-ALLs. GC-resistant non-ETP T-ALLs are characterized by strong induction of JAK/STAT signaling in response to interleukin-7 stimulation. Removing IL7 or inhibiting JAK/STAT signaling sensitizes these T-ALLs, and a subset of ETP T-ALLs, to GCs. The combination of the GC dexamethasone and the JAK1/2 inhibitor ruxolitinib altered the balance between pro- and anti-apoptotic factors in samples with IL7-dependent GC resistance, but not in samples with IL7-independent GC resistance. Together, these data suggest that the addition of ruxolitinib or other inhibitors of IL7 receptor/JAK/STAT signaling may enhance the efficacy of GCs in a biologically defined subset of T-ALL.Leukemia advance online publication, 30 May 2017; doi:10.1038/leu.2017.136. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Intertextual Biography in the Rivalry of Cratinus and AristophanesZachary P. BilesMore than a decade ago, Malcolm Heath provided an influential explanation for charges of plagiarism between comic poets when he posited a growing store of ideas that were recycled as quickly as they were invented. As a result, "Anything put on stage in a comedy would become public property and be absorbed into the repertoire, so that all comic (...) poets contributed to it; and all drew on it, although each would aim to give a new and original twist to the material which he borrowed, so that the repertoire constantly evolved. If this was so, then any poet could lay claim to originality... and any rival could make a counterclaim of plagiarism."1 These remarks have important implications for the study of Old Comedy, not least in exposing the irony of such assertions as that of Antiphanes (Poiēsis, fr. 189 K-A), which overstates generic distinctions between tragedy and comedy on the score of originality. Beyond merely acknowledging comedy's essentially adaptive nature, Heath's position suggests that a certain degree of allusiveness was, as it were, built into the genre. Unfortunately there are few opportunities to test the potential insights that follow from Heath's general proposition since the corpus of comic fragments poses so many questions of plot, context, attribution, and-always important for this kind of study-chronology.There is one sequence of plays, however, that has attracted attention since antiquity as an example of comic poets responding to one another and for which valuable insights can still be gained by building on Heath's thesis. In 423 Cratinus took the prize against Aristophanes' Clouds with Pytine, a play in which Cratinus boldly portrayed himself as the hero while borrowing heavily from Aristophanes' caricature of him in Knights the previous year. While interest in the relationship of these plays has been renewed in recent years, the convergence of issues pertaining to adaptation, intertextuality, and rivalry has not been fully explored. Besides discussing these ideas as they relate to Knights and [End Page 169] Pytine, I shall extend the thread of artistic borrowing at either end, first by positing a stage autobiography of Cratinus that both predates and inspired Knights, and then by tracing elements of intertextuality between Wasps and Pytine. Generally speaking Heath's model proves to be of great value; however, my study makes an important modification by treating competition as a vital aspect of comic poetry.2 The intertextuality of these plays primarily depends on poetic biography, and the notion of competition is central to my understanding of stage biography as comic poets employed it either to assert their own superiority or malign their rivals. After examining the biographical interplay in the rivalry of Cratinus and Aristophanes, I end by applying the intertextual model more generally to Wasps, a play that advertises itself as a competitive response and whose intertextual relationship with Pytine can be viewed as a function of competitive strategy.IThe trail of evidence begins with a scholion on Knights 400. Commenting on the chorus's elusive response to Cleon ("If I don't despise you, may I become a blanket in Cratinus' house!"), the scholiast writes:(= Pytine test. ii K-A)3 [End Page 170]Certain errors about Cratinus' retirement aside,4 the scholiast shows himself to be a reliable witness to the play by his knowledge of the plot and ability to cite the text in the continuation of his commentary (fr. 193). Thus, with the exception of treating the more fully developed caricature of Cratinus as a drunk in the Knights parabasis as the actual source of inspiration for his self-portrayal in Pytine, generations of scholars have followed the scholiast's characterization of Pytine as a redemptive play, however exaggerated this biographical (mis)representation may have been in both plays. Two recent studies have raised objections to the traditional understanding of Knights and Pytine. Troubled by a certain feeling of allusiveness in the jokes about Cratinus in Knights and Acharnians, Keith Sidwell hypothesizes a source for the audience's familiarity with details of Cratinus' life by arguing that his stage "biography " was not an Aristophanic... (shrink)

Typically, fair machine learning research focuses on a single decision maker and assumes that the underlying population is stationary. However, many of the critical domains motivating this work are characterized by competitive marketplaces with many decision makers. Realistically, we might expect only a subset of them to adopt any non-compulsory fairness-conscious policy, a situation that political philosophers call partial compliance. This possibility raises important questions: how does partial compliance and the consequent strategic behavior of decision subjects affect the allocation outcomes? (...) If k% of employers were to voluntarily adopt a fairness-promoting intervention, should we expect k% progress (in aggregate) towards the benefits of universal adoption, or will the dynamics of partial compliance wash out the hoped-for benefits? How might adopting a global (versus local) perspective impact the conclusions of an auditor? In this paper, we propose a simple model of an employment market, leveraging simulation as a tool to explore the impact of both interaction effects and incentive effects on outcomes and auditing metrics. Our key findings are that at equilibrium: (1) partial compliance by k% of employers can result in far less than proportional (k%) progress towards the full compliance outcomes; (2) the gap is more severe when fair employers match global (vs local) statistics; (3) choices of local vs global statistics can paint dramatically different pictures of the performance vis-a-vis fairness desiderata of compliant versus non-compliant employers; (4) partial compliance based on local parity measures can induce extreme segregation. Finally, we discuss implications for auditors and insights concerning the design of regulatory frameworks. (shrink)

The need for informed analyses of health policy is now greater than ever. The twelve essays in this volume show that public debates routinely bypass complex ethical, sociocultural, historical, and political questions about how we should address ideals of justice and equality in health care. Integrating perspectives from the humanities, social sciences, medicine, and public health, this volume illuminates the relationships between justice and health inequalities to enrich debates. Understanding Health Inequalities and Justice explores three questions: How do scholars approach (...) relations between health inequalities and ideals of justice? When do justice considerations inform solutions to health inequalities, and how do specific health inequalities affect perceptions of injustice? And how can diverse scholarly approaches contribute to better health policy? From addressing patient agency in an inequitable health care environment to examining how scholars of social justice and health care amass evidence, this volume promotes a richer understanding of health and justice and how to achieve both. -/- The contributors are Judith C. Barker, Paula Braveman, Paul Brodwin, Jami Suki Chang, Debra DeBruin, Leslie A. Dubbin, Sarah Horton, Carla C. Keirns, J. Paul Kelleher, Nicholas B. King, Eva Feder Kittay, Joan Liaschenko, Anne Drapkin Lyerly, Mary Faith Marshall, Carolyn Moxley Rouse, Jennifer Prah Ruger, and Janet K. Shim. (shrink)

Aaron Zimmerman presents a new pragmatist account of belief, in terms of information poised to guide our more attentive, controlled actions. And he explores the consequences of this account for our understanding of the relation between psychology and philosophy, the mind and brain, the nature of delusion, faith, pretence, racism, and more.

Constitutivist accounts of self-knowledge argue that a noncontingent, conceptual relation holds between our first-order mental states and our introspective awareness of them. I explicate a constitutivist account of our knowledge of our own beliefs and defend it against criticisms recently raised by Christopher Peacocke. According to Peacocke, constitutivism says that our second-order introspective beliefs are groundless. I show that Peacocke’s arguments apply to reliabilism not to constitutivism per se, and that by adopting a functionalist account of direct accessibility a constitutivist (...) can avoid reliabilism. I then argue that the resulting view is preferable to Peacocke’s own account of self-knowledge. (shrink)

Statʹi, razmyshlenii︠a︡, ocherki -- Pisʹma v redakt︠s︡ii -- Perepiska s chlenami Soi︠u︡za svobodomysli︠a︡shchikh -- Pisʹma k M.I. Barskoĭ -- Perepiska mezhdu K.P. Krizhanovskim i I.G. Khusidom -- Iz materialov dela K.P. Krizhanovskogo.

Práce, která uvádí do živé problematiky vědecké estetiky, řeší v první části problémy a úkoly estetiky, obrací se k jejímu předmětu, ke krásnu a umění, obírá se významem signální teorie pro estetiku, poměrem člověka k obrazu astavbě i pokrokem v hudbě a umění vůbec. Do druhé části jsou zařazeny vybrané kapitoly jednak z dějin řecké, jednak z české estetiky.

[1] Elul. Yamim Noraʼim. Sukot -- [2] Pesaḥ. Shevuʻot. Galut u-geʼulot. Ḥanukah. Purim.

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The article explores the main cloud technology models. The reasoned choice of the SaaS model for creating a Web application for educational process information support has been made. A software tool environment has been formed, including Heroku, ClearDB, MySQL SSL, Apache Maven to support the design and operation of the application. Roles and functionality for each user of the application are developed. The possibilities of access to it, changes and replenishment are determined.

Because the evolution of speech production is beyond our expertise (and perhaps beyond everyone's expertise) we restrict our comments to areas in which data actually exist. We provide articulatory evidence consistent with the claims made about syllable structure in adult speech and infant babbling, but we also voice some disagreement about speech errors and the typing data.